Multi-site assessment of rapid, point-of-care antigen testing for the diagnosis of SARS-CoV-2 infection in a low-prevalence setting: A validation and implementation study

S Muhi; N Tayler; T Hoang; SA Ballard; M Graham; A Rojek; JC Kwong; JA Trubiano; O Smibert; G Drewett; F James; E Gardiner; S Chea; N Isles; M Sait; S Pasricha; G Taiaroa; J McAuley; E Williams; KB Gibney; TP Stinear; K Bond; SR Lewin; M Putland; BP Howden; DA Williamson

Journal article

Multi-site assessment of rapid, point-of-care antigen testing for the diagnosis of SARS-CoV-2 infection in a low-prevalence setting: A validation and implementation study

S Muhi, N Tayler, T Hoang, SA Ballard, M Graham, A Rojek, JC Kwong, JA Trubiano, O Smibert, G Drewett, F James, E Gardiner, S Chea, N Isles, M Sait, S Pasricha, G Taiaroa, J McAuley, E Williams, KB Gibney Show all

Lancet Regional Health Western Pacific | ELSEVIER | Published : 2021

DOI: 10.1016/j.lanwpc.2021.100115

Download PDF

Abstract

Background: In Australia, COVID-19 diagnosis relies on RT-PCR testing which is relatively costly and time-consuming. To date, few studies have assessed the performance and implementation of rapid antigen-based SARS-CoV-2 testing in a setting with a low prevalence of COVID-19 infections, such as Australia. Methods: This study recruited participants presenting for COVID-19 testing at three Melbourne metropolitan hospitals during a period of low COVID-19 prevalence. The Abbott PanBioTM COVID-19 Ag point-of-care test was performed alongside RT-PCR. In addition, participants with COVID-19 notified to the Victorian Government were invited to provide additional swabs to aid validation. Implementati..

View full abstract

University of Melbourne Researchers

Stephen Muhi Author

Jason Kwong Author

Jason Trubiano Author

Michelle Sait Author

Related Projects (4)

IMPROVING PREVENTION, TRACKING AND TREATMENT OF MAJOR HUMAN BACTERIAL PATHOGENS

This research fellowship will lead to a detailed understanding of the mechanisms by which bacteria become resistant to antibiotics and cause..

MOBILITY, MIXING AND INFECTIOUS DISEASE TRANSMISSION AMONG REMOTE-LIVING INDIGENOUS AUSTRALIANS: ADDRESSING A KNOWLEDGE GAP TO IDENTIFY EFFECTIVE STRATEGIES FOR SUSTAINED DISEASE CONTROL

Indigenous Australians in remote communities experience extremely high rates of infections such as skin sores. I will study the mobility and..

THE METAFIND (METAGENOMICS FOR INFECTIOUS DISEASES) PROJECT: DEVELOPING CLINICAL METAGENOMICSTO IMPROVE THE HEALTHCARE OF PATIENTS WITH INFECTIONS

The MetaFIND (Metagenomics For INfectious Diseases) project is a combined laboratory and clinical study that aims to develop and investigate..

APPLYING PATHOGEN GENOMICS TO THE PREVENTION AND CONTROL OF ANTIMICROBIAL RESISTANCE

Antimicrobial resistance (AMR) is a huge threat to public health, both in Australia and globally. In some instances, having an AMR infection..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was funded by the Victorian Department of Health and Human Services. The funder was not involved in data analysis or manuscript preparation.